Mainly, we use functional and structural magnetic resonance imaging (MRI) to study both clinical and healthy participants. For instance, we may follow individuals over time while being treated with and anxiolytic treatment. We also have ongoing research on the brain's plasticity and the interaction with cell biology, such as leucocyte telomere length, and telomerase activity. Different methodological approaches are used, e.g., BOLD-fMRI variability, and support vector machine (SVM) learning. This research may lead to developments of novel and effective treatments for common psychiatric disorders.

In addition, I'm also the study director for the research school in clinical psychiatry at Karolinska Institutet. Also, I participate as a researcher in a neuroimaging study at Uppsala university. Post-doc supervisor at Stockholm University: Professor Håkan Fischer.
 

Kristoffer Månsson. Foto: Ulrica Zwenger
Kristoffer Månsson. Foto: Ulrica Zwenger

 

Primary investigator

Kristoffer Månsson, PhD, Study Director (at Karolinska Institutet), Clinical Psychologist

Post doc, Department of Psychology, Stockholm University
Study director, Psychiatry Research School, Department of Clinical Neuroscience, Karolinska Institutet
Researcher, Department of Psychology, Uppsala University

E-mail: kristoffer.mansson@psychology.su.se

Phone: +46 (0)70 580 3267

Current research projects

  1. The brain’s plasticity and cellular aging in social anxiety disorder. We study neurobiological effects by a psychological treatment for social anxiety disorder. We are interested in how the brain's structural plasticity, and neural responses, interacts with cellular health markers such as telomere length and telomerase activity. This study is a collaboration with professor Tomas Furmark (Uppsala University) and Daniel Lindqvist (Lund University). Also, in collaboration with Douglas Garrett's lab (Max Planck Institute for Human Development, Berlin), we explore neural response variability (BOLD-fMRI variability)
  2. Oxytocin and neuroplasticity. In this double-blind placebo-controlled study on oxytocin, we explore the effects of oxytocin on emotions and the brain's neuroplasticity (PI: professor Håkan Fischer). Data is collected in both Stockholm and Florida and is a close collaboration with Natalie Ebner's lab (University of Flordia).
  3. Clinical psychologists ability to identify feelings of others. Here, we study the effect of training junior clinical psychologist to improve their skill to identify other people's feelings. We are interested in understanding how these improvements are represented in the brain. The study is a collaboration with professor Håkan Fischer, professor Stephan Hau (PI) and Diana Cortes (and many more) at Stockholm University.

Other Ongoing Research Projects

  • Using support vector machine (SVM) learning to classify the brain’s age and gender
  • Sleepiness induced changes in the brain’s morphology
  • Internet-delivered support in psychological treatments face-to-face: hoarding disorder, and Parkinson’s disease
Månssons brain
An anatomical brain image acquired on a 3 Tesla MRI scanner

 

Collaborators at the Department of Psychology, Stockholm university

  • Manzouri Amirhossein, MSc, Research Engineer
  • Diana S. Cortes, MSc, PhD Student
  • Håkan Fischer, PhD, Professor
  • Stephan Hau, PhD, Professor
  • Hedvig Söderlund, PhD, Professor

Collaborators at Other Institutions and Departments

  • Gerhard Andersson, PhD, Professor, Linköping University, Karolinska Institutet
  • Carl-Johan Boraxbekk, PhD, Umeå University
  • Andreas Frick, PhD, Stockholm University, Uppsala University
  • Tomas Furmark, PhD, Professor, Uppsala University
  • Agneta Herlitz, PhD, Professor, Karolinska Institutet
  • Volen Ivanov, PhD, Karolinska Institutet
  • Martin Kraepelien, MSc, Karolinska Institutet
  • Catharina Lavebratt, PhD, Karolinska Institutet
  • Mats Lekander, PhD, Professor, Stockholm University, Karolinska Institutet
  • Daniel Lindqvist, PhD, Lunds University
  • Gustav Nilsonne, PhD, Stockholm University, Karolinska Institutet
  • Predrag Petrovic, PhD, Karolinska Institutet
  • Christian Rück, PhD, Karolinska Institutet
  • Torbjörn Åkerstedt, PhD, professor, Stockholm University, Karolinska Institutet

International Collaborators

  • Natalie Ebner, PhD, University of Florida, United States
  • Douglas Garrett, PhD, Max Planck Institute for Human Development, Berlin, Germany
  • Andre F Marquand, PhD, Radboud University, Nijmegen, Netherlands
  • Owen Wolkowitz, PhD, Professor, University of California, San Francisco, United States

Supervised Theses (Candidate and Master Degrees)

  • Anna Chantre (2017), Svenska Institutet för Kognitiv Psykoterapi
  • Björn von Gegerfelt and Markus Söderqvist (2017), Karolinska Institutet
  • Nils Isacsson and Örn Kolbeinsson (2016), Linköping University
  • Erica Skagius Ruiz and Elisabeth Gervind (2012), Linköping University
  • Adam Yngve (2016), Linköping University

Funding

  • Carlo Perris Minnesfond och stipendium från ICCP (2017)
  • Psykiatrifonden (2015)
  • Centrum för psykiatriforskning (2014, 2015)
  • PRIMAs Forskningsfond (2013)
  • Capio Forskningsstiftelse (2011, 2012)

Publications (Peer-reviewed)

Updated 2017-10-19.

Lenhard, F., Sauer, S., Andersson, E., Mansson, K. N., Mataix-Cols, D., Ruck, C., & Serlachius, E. (in press). Prediction of outcome in internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: A machine learning approach. Int J Methods Psychiatr Res. doi:10.1002/mpr.1576

Faria, V., Gingnell, M., Hoppe, J. M., Hjorth, O., Alaie, I., Frick, A., Hultberg, S., Wahlstedt, K., Engman, J., Månsson, K. N. T., Carlbring, P., Andersson, G., Reis, M., Larsson, E.-M., Fredrikson, M., & Furmark, T. (in press). Do you believe it? Verbal suggestions influence the clinical and neural effects of escitalopram in social anxiety disorder: a randomized trial. EBioMedicine. doi:10.1016/j.ebiom.2017.09.031

Bas-Hoogendam, J. M., van Steenbergen, H., Nienke Pannekoek, J., Fouche, J.-P., Lochner, C., Hattingh, C. J., Cremers, H. R., Furmark, T., Månsson, K. N. T., Frick, A., Engman, J., Boraxbekk, C.-J., Carlbring, P., Andersson, G., Fredrikson, M., Straube, T., Peterburs, J., Klumpp, H., Phan, K. L., Roelofs, K., Veltman, D. J., van Tol, M.-J., Stein, D. J., & van der Wee, N. J. A. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage: Clinical, 16, 678-688. doi:10.1016/j.nicl.2017.08.001

Månsson, K. N. T., Klintmalm, H., Nordqvist, R., & Andersson, G. (2017). Conventional cognitive behaviour therapy facilitated by an internet-based support system: a feasibility study at a psychiatric outpatient clinic. JMIR Research Protocols, 6:e158.

Månsson, K. N. T., Salami, A., Carlbring, P., Boraxbekk, C.-J., Andersson, G., & Furmark, T. (2017). Structural but not functional neuroplasticity one year after effective cognitive behaviour therapy for social anxiety disorder. Behavioural Brain Research, 318, 45–51.

Månsson, K. N. T., Salami, A., Frick, A., Carlbring, P., Andersson, G., Furmark, T., Boraxbekk, C. J. (2016). Neuroplasticity in response to cognitive behavior therapy for social anxiety disorder. Translational Psychiatry, 6:e727. doi:10.1038/tp.2015.218

Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2016). The initial evaluation of an internet-based support system for audiologists and first-time hearing aid clients. Internet Interventions, 4, 82-91.

Månsson, K. N. T., Frick, A., Boraxbekk, C. J., Marquand, A. F., Williams, S. C., Carlbring, P., Andersson, G., & Furmark, T. (2015). Predicting long-term outcome of cognitive behavior therapy for social anxiety disorder using fMRI and support vector machines. Translational Psychiatry, 5:e530. doi:10.1038/tp.2015.22

Nilsonne, G., Tamm, S., Månsson, K. N. T., Åkerstedt, T., & Lekander, M. (2015). Leukocyte telomere length and hippocampus volume: a meta-analysis. F1000Research, 4:1073.

Tulbure, B. T., Szentagotai, A., David, O., Stefan, S., Månsson, K. N. T., David, D., & Andersson, G. (2015). Internet-delivered cognitive-behavioral therapy for social anxiety disorder in Romania: a randomized controlled trial. PloS ONE, 10(5):e0123997.

Brännström, K. J., Öberg, M., Ingo, E., Månsson, K. N. T., Andersson, G., Lunner, T., & Laplante-Lévesque, A. (2015). The process of developing an internet-based support system for audiologists and first-time hearing aid clients. American Journal of Audiology, 24, 320-324.

Månsson, K. N. T., Carlbring, P., Frick, A., Engman, J., Olsson, C.-J., Bodlund, O., Furmark, T., & Andersson, G. (2013). Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. Psychiatry Research, 214(3), 229-37.

Månsson, K. N. T., Skagius Ruiz, E., Gervind, E., Dahlin, M., & Andersson, G. (2013). Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. J Med Internet Res., 15(12):e280.

Tulbure, B. T., Månsson, K. N. T., & Andersson, G. (2012). Internet treatment for social anxiety disorder in Romania: Study protocol for a randomized controlled trial. Trials, 12:302.